Promising New Molecule Developed at Israel May Prevent Age-Related Diseases and Increase Life Expectancy and Wellness.
With a constant renewal of cell vitality in diseased tissues, this new drug will hopefully lead to the treatment or prevention of diseases, such as Alzheimer’s and Parkinson’s
While breakthroughs in the world of medicine and technology account for the global increase in life expectancy, improvements in quality of life for the elderly population lag far behind.
Longevity without a decline in health is one of the major challenges that face the world of medicine.
A new study led by Professors Einav Gross and Shmuel Ben-Sasson has identified a group of molecules that enable cells to repair damaged components, making it possible for those tissues to retain proper function.
The efficacy of the molecules was demonstrated on a model organism. The research team examined the effect of various therapies on longevity and quality of life, and successfully proved they can protect the organisms and human cells from damage. Their findings were published in Autophagy.
Currently, a major factor in aging tissues is the reduced effectiveness of the cell’s quality-control mechanism, which leads to the accumulation of defective mitochondria.
As Gross explained, “mitochondria, the cell’s ‘power plants,’ are responsible for energy production. They can be compared to tiny electric batteries that help cells function properly.
Although these ‘batteries’ wear out constantly, our cells have a sophisticated mechanism that removes defective mitochondria and replaces them with new ones.”
However, this mechanism declines with age, leading to cell dysfunction and deterioration in tissue activity.
This degenerative process lies at the heart of many age-related diseases, such as Alzheimer’s disease, Parkinson’s disease, heart failure and sarcopenia, which are on the rise. Gross and Ben-Sasson’s study may have far-reaching practical applications since their new technology, helped create innovative compounds to treat diseases that are currently incurable.
The study also showed that these molecules can be used preventively. “In the future, we hope we will be able to significantly delay the development of many age-related diseases and improve people’ quality of life,” shared Ben-Sasson.
Further, these compounds are user-friendly and can be taken orally.